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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Periodontitis and systemic parameters in chronic kidney disease: Systematic review and meta-analysis
Suélem Maria Santana Pinheiro Ferreira1, Isaac Suzart Gomes-Filho1, Maria da Conceição Nascimento Costa2
1Department of Health, Feira de Santana State University (UEFS), Feira de Santana, Brazil.
Oral Diseases
|May 9, 2024
Summary
Periodontitis is linked to poorer health outcomes in chronic kidney disease (CKD) patients. This systematic review found associations between periodontitis and abnormal serum markers, cardiovascular disease death, and all-cause mortality in CKD individuals.
Area of Science:
- Nephrology and Periodontology
- Systematic Review and Meta-Analysis
- Chronic Kidney Disease (CKD) Research
Background:
- Periodontitis, a common oral infection, may influence systemic health, particularly in patients with chronic kidney disease (CKD).
- Understanding the association between periodontitis and CKD progression or outcomes is crucial for patient management.
- Recent scientific evidence needs systematic evaluation to clarify this relationship.
Approach:
- A comprehensive systematic review and meta-analysis was conducted.
- Searches were performed across major scientific databases (MedLine/PubMed, Scopus, Web of Science, BIREME).
- Eligible studies were assessed for quality, and data were synthesized using random-effects meta-analysis.
Key Points:
- Periodontitis was significantly associated with hypoalbuminemia (PR=2.47).
- Elevated C-reactive protein levels were linked to periodontitis (PR=1.35).
- Periodontitis showed associations with increased risk of death from cardiovascular disease (RR=2.29) and all causes (RR=1.73).
Conclusions:
- This review confirms a positive association between periodontitis and adverse systemic markers in CKD patients.
- The findings highlight the potential impact of oral health on the prognosis of individuals with chronic kidney disease.
- Further research may explore therapeutic interventions targeting periodontitis to improve CKD outcomes.
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