Related Experiment Video
Updated: Jun 26, 2025

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-Cyano-2-iso-nitro-soacetamide-3,4-di-methylpyrazole (1/1): a co-crystal of two mol-ecules with agrochemical
Kostiantyn V Domasevitch1, Ganna A Senchyk1, Vira V Ponomarova1
1Inorganic Chemistry Department, National Taras Shevchenko University of Kyiv, Volodymyrska Str. 64/13, 01601 Kyiv, Ukraine.
Abstract:
In the structure of the title co-crystal, C3H3N3O2·C5H8N2, the components are linked by a set of directional O-H⋯N, N-H⋯O, N-H⋯N and C-H⋯O hydrogen bonds to yield a two-dimensional mono-periodic arrangement. The structure propagates in the third dimension by extensive π-π stacking inter-actions of nearly parallel mol-ecules of the two components, following an alternating sequence. The primary structure-defining inter-action is very strong oxime-OH donor to pyrazole-N acceptor hydrogen bond [O⋯N = 2.587 (2) Å], while the significance of weaker hydrogen bonds and π-π stacking inter-actions is comparable. The distinct structural roles of different kinds of inter-actions agree with the results of a Hirshfeld surface analysis and calculated inter-action energies. The title compound provides insights into co-crystals of active agrochemical mol-ecules and features the rational integration in one structure of a fungicide, C3H3N3O2, and a second active component, C5H8N2, known for alleviation the toxic effects of fungicides on plants. The material appears to be well suited for practical uses, being non-volatile, air-stable, water-soluble, but neither hygroscopic nor efflorescent.
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Structures of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the...
2° Amines to N-Nitrosamines: Reaction with NaNO2
Diazonium Group Substitution: –OH and –H
Structure of Amines

