[Detection of T cell independent B cell maturation disorder in cocultivation studies in systemic lupus erythematosus]

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

T Schlegelberger, J Kekow, W L Gross

    Immunitat Und Infektion
    |February 1, 1985
    PubMed

    Abstract:

    Lymphocyte coculture experiments were performed in a case of monozygotic twins, discordant for SLE. Lack of responsiveness to T-cell-dependent and independent B-cell stimulation gave evidence of an intrinsic B-cell defect in the SLE twin.

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