Related Experiment Video
Updated: Jun 26, 2025
10:26
Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
26.3K
Pharmacotherapy in Stress Urinary Incontinence; A Literature Review.
Seyed Sajjad Tabei1, Wesley Baas1, Ayman Mahdy2,3
1Division of Urology, Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.
Current Urology Reports
|May 10, 2024
Summary
Current pharmacotherapy for stress urinary incontinence (SUI) offers limited benefits, with risks often outweighing rewards. Emerging targets show promise for improved SUI treatment in both women and men.
Area of Science:
- Urology
- Pharmacology
- Gerontology
Background:
- Stress urinary incontinence (SUI) affects many women and men post-prostatectomy.
- Current pharmacotherapy for SUI has shown limited clinical success.
- Surgical advancements have not fully addressed SUI treatment gaps.
Purpose of the Study:
- To review current pharmacotherapy options for SUI.
- To explore emerging therapeutic targets for SUI treatment.
- To provide a comprehensive overview of SUI drug therapies.
Main Methods:
- Literature review of pharmacotherapy for SUI.
- Analysis of meta-analyses and clinical trials.
- Identification of approved and investigational SUI drugs.
Main Results:
- Alpha-adrenergic drugs offer symptom improvement, not cures for SUI.
- Duloxetine's risks may exceed its benefits for SUI.
- Locally administered estriol shows potential for subjective SUI improvement.
- Emerging targets include serotonin 5HT2C agonists and myostatin inhibitors.
- Systemic side effects limit the efficacy of current SUI medications.
Conclusions:
- Existing SUI pharmacotherapy has significant limitations.
- Novel therapeutic targets are under investigation for SUI.
- Further research is needed to develop effective and safe SUI treatments.
Related Concept Videos
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
196
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
196
01:26The Micturition Reflex
575
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
575
01:23Urinary Bladder
635
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
635
01:17Drugs for Treatment of Diarrhea-Predominant IBS
161
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
161
01:21Drugs for Treatment of Constipation-Predominant IBS
160
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
160
01:27Introduction to Stress and Lifestyle
104
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
104