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Updated: Jun 26, 2025

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
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Structural dynamics in α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor gating

Cuauhtemoc U Gonzalez1, Vasanthi Jayaraman2

  • 1Center for Membrane Biology, Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; MD Anderson Cancer Center and UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Electronic address: https://twitter.com/Cuau_Ulises.

Current Opinion in Structural Biology
|May 11, 2024
PubMed
Summary

Ionotropic glutamate receptors (iGluRs), like AMPA receptors, are crucial for neuronal plasticity. Recent structural studies reveal how these receptors change shape and interact with auxiliary proteins to control neuronal signaling.

Keywords:
ActivationCryo-EMDynamicsGlutamate receptorsTransmembrane AMPA-receptor regulatory protein (TARP)α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)

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