[Immunodiagnosis and immunotherapy of chronic nonspecific lung diseases]

Altogether 212 patients with chronic nonspecific pulmonary diseases (CNPD) were examined. Of these, 105 patients received treatment with sodium nucleinate, 72 with levamisole, 17 with diucifon and 18 with T-activin. As compared with healthy subjects, the patients manifested significantly deviated immunological parameters. CNDP patients showed a decrease in the T and B lymphocyte counts, unbalance in the levels of immunoglobulins (IgA, IgM, IgG). The immunocorrective therapy lead to equalization of the immunity parameters in the majority of cases. Levamisole and diucifon appeared of value from the standpoint of their effect on the immunity parameters. Sodium nucleinate was less effective. T-activin caused an elevation of the T lymphocyte count in all the patients. Normalization of the immunity caused by the immunocorrective therapy correlated with a beneficial clinical effect.