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Causal relationship between gut microbiota and differentiated thyroid cancer: a two-sample Mendelian randomization
Shaojun Hu1, Chuangang Tang2, Ling Wang3
1Department of Oncology, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China.
Frontiers in Oncology
|May 13, 2024
Summary
This study used Mendelian randomization to investigate the gut microbiota
Area of Science:
- Microbiome research
- Genetics
- Oncology
Background:
- The gut microbiota is linked to differentiated thyroid cancer (DTC), but a causal relationship is not established.
- Understanding the gut microbiome's role in DTC pathogenesis is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the causal relationship between gut microbiota and differentiated thyroid cancer (DTC).
- To identify specific bacterial taxa associated with increased or decreased DTC risk.
Main Methods:
- Utilized genome-wide association study (GWAS) summary data for exposures and outcomes.
- Employed Mendelian randomization (MR) to infer causality.
- Conducted sensitivity analyses to validate findings.
Main Results:
- Identified four bacterial traits positively associated with DTC risk: Class Mollicutes, Phylum Tenericutes, Genus Eggerthella, and Order Rhodospirillales.
- Found four bacterial traits negatively associated with DTC risk: Genus Eubacterium fissicatena group, Genus Lachnospiraceae UCG008, Genus Christensenellaceae R-7 group, and Genus Escherichia Shigella.
- Noted potential impact of small sample size on confidence intervals for certain taxa.
Conclusions:
- Established potential causal links between specific gut bacteria and differentiated thyroid cancer.
- Findings offer insights into DTC's pathological mechanisms.
- Results may inform novel clinical strategies for DTC treatment.
