Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pedigree Analysis

Pedigree Analysis

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy of repetitive transcranial magnetic stimulation for post-stroke spasticity: a meta-analysis of randomized controlled trials.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same author

Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis.

Nature communications·2026

Same author

12-Month Clinical Outcomes Using a Variable-Loop Circular Catheter for PFA in a Chinese Atrial Fibrillation Population.

Pacing and clinical electrophysiology : PACE·2026

Same author

Where to Perform the Pulmonary Vein Isolation in Third-Ablation Paroxysmal AF?

Pacing and clinical electrophysiology : PACE·2026

Same author

A new mapping and ablation strategy for premature ventricular complexes originating from the proximal left anterior fascicle under the guidance of electrocardiographic characteristics.

Heart rhythm·2026

Same author

Three-dimensional reconstruction of densely planted rice seedlings based on MultiView images.

Plant phenomics (Washington, D.C.)·2026

Same journal

Clinical spectrum, familial patterns, and surgical interventions in patients with cleft lip and/or palate: experience from a specialized cleft care center in Pakistan.

World journal of pediatric surgery·2026

Same journal

Expert consensus on surgical management of unilateral Wilms tumor (2025).

World journal of pediatric surgery·2026

Same journal

Endoscopic retrograde appendiceal irrigation for children with recurrent abdominal pain and appendiceal fecaliths: a retrospective cohort study.

World journal of pediatric surgery·2026

Same journal

Current operative approaches for necrotizing enterocolitis.

World journal of pediatric surgery·2026

Same journal

Family perspective: raising a child with NEC and the need for multidisciplinary care.

World journal of pediatric surgery·2026

Same journal

Feasibility of neonatal intravenous nutrition for the management of gastroschisis in sub-Saharan Africa.

World journal of pediatric surgery·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 26, 2025

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

Exploring causality with biliary atresia at different levels: two-sample Mendelian randomization study.

Shaowen Liu^1,2, Jiayinaxi Musha^1,3, Zhiru Wang^1,2

¹Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.

World Journal of Pediatric Surgery

|May 13, 2024

Summary

This summary is machine-generated.

Mendelian randomization identified seven traits causally linked to biliary atresia (BA). Certain inflammatory cytokines and metabolites are risk factors, while specific immune cell traits offer protection, advancing BA etiology understanding.

Keywords:

Genetics Immunization Information Technology Pediatrics Statistics

More Related Videos

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

Related Experiment Videos

Last Updated: Jun 26, 2025

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

Area of Science:

Genetics
Immunology
Metabolomics

Background:

Mendelian randomization (MR) is a powerful tool for inferring causality in disease risk.
Its application to biliary atresia (BA) has been previously unexplored.

Purpose of the Study:

To investigate the causal relationships between inflammatory cytokines, immune cell traits, metabolites, and biliary atresia (BA) using MR.
To establish a genetic basis for BA etiology and potential therapeutic targets.

Main Methods:

Utilized genome-wide association studies (GWAS) data for exposures (cytokines, immune cells, metabolites) and BA.
Employed inverse variance weighting as the primary MR analysis.
Conducted sensitivity analyses including Cochran Q-test, MR-Egger, and leave-one-out methods to ensure result validity.

Main Results:

Identified seven traits with potential causal links to BA.
Eotaxin, G-CSF, MCP-1/MCAF, and X-12261 levels were associated as risk factors.
CD8dim NKT/T cells ratio, CD8dim NKT counts, and CD8dim NKT/lymphocyte ratio showed protective associations.

Conclusions:

This study provides the first MR evidence implicating specific inflammatory cytokines, metabolites, and immune cell traits in BA pathogenesis.
Findings suggest potential biomarkers and therapeutic avenues for biliary atresia.