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Updated: Jun 26, 2025

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Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
Published on: May 25, 2015
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Bilateral Phrenic Nerve Palsy Associated With Neuralgic Amyotrophy
Wataru Shiraishi1,2, Yuichi Murata3, Yukiko Inamori1
1Neurology, Kokura Memorial Hospital, Kitakyushu, JPN.
Cureus
|May 13, 2024
Summary
Neuralgic amyotrophy, a rare nerve condition, can affect the diaphragm. This case highlights bilateral phrenic nerve palsy in a patient with neuralgic amyotrophy, causing breathing difficulties.
Area of Science:
- Neurology
- Immunology
Background:
- Neuralgic amyotrophy (NA) is an inflammatory neuropathy typically affecting the upper extremities.
- Phrenic nerve involvement is an uncommon manifestation of NA.
Observation:
- A male patient presented with neck pain, orthopnea, and supine hypoxemia.
- Physical examination revealed right shoulder muscle atrophy and an inability to slurp.
- Diagnostic tests confirmed bilateral phrenic nerve palsy.
Findings:
- The patient was diagnosed with bilateral phrenic nerve palsy secondary to neuralgic amyotrophy.
- This case demonstrates a rare presentation of NA involving the diaphragm.
Implications:
- NA can lead to significant respiratory compromise through phrenic nerve involvement.
- Recognizing NA as a cause of phrenic palsy is crucial for timely diagnosis and management.
- This case underscores the importance of considering NA in patients with unexplained respiratory symptoms and diaphragmatic dysfunction.
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