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Updated: May 5, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Formulation design and characterization of silymarin liposomes for enhanced antitumor activity
Zhongcheng Ke1, Xiaoling Cheng2, Huimin Yang3
1College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, China/Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan, Anhui, China/College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Abstract:
Liposomes, a nanoscale carrier, plays an important role in the delivery of drug, affects the in vivo efficacy of drugs. In this paper, silymarin(SM)-loaded liposomes was optimized using the response surface method (RSM), with entrapment efficiency (EE%) as an index. The formulation was optimized as follow: lecithin (7.8mg/mL), SM/lecithin (1/26) and lecithin/cholesterol (10/1). The optimized SM liposomes had a high EE (96.58 ±3.06%), with a particle size of 290.3 ±10.5nm and a zeta potential of +22.98 ±1.73mV. In vitro release tests revealed that SM was released in a sustained-release manner, primarily via diffusion mechanism. In vitro cytotoxicity studies demonstrated that the prepared SM liposomes had stronger inhibitory effects than the model drug. Overall, these results indicate that this liposome system is suitable for intravenous delivery to enhance the antitumor effects of SM.
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