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Updated: Jun 26, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies
Published on: October 25, 2018
[AChR Antibody-Positive Myasthenia Gravis]
1Department of Neurology, School of Medicine, International University of Health and Welfare.
None:
Herein, we describe the mechanisms, diagnostic procedures, and treatment options for acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG). The upstream pathomechanism of this condition involves AChR-sensitized T cell-dependent B cell proliferation and the subsequent production of pathogenic autoantibodies. Downstream molecules include AChR antibodies that activate complement pathways, resulting in the destruction of motor endplates. We further introduce newly-developed molecular targeted drugs for the treatment of MG that aims to secure patients' health-related quality of life.
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