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    Digital defocus correction in time-domain full-field optical coherence tomography (TD-FF-OCT) overcomes image degradation in scattering media. This technique compensates for up to 1 mm of defocus, enhancing imaging depth in biomedical applications.

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    Area of Science:

    • Biomedical Optics
    • Optical Imaging
    • Coherent Tomography

    Background:

    • Time-domain full-field optical coherence tomography (TD-FF-OCT) offers high-resolution deep tissue imaging.
    • Optical aberrations like sample defocus limit TD-FF-OCT's imaging depth and quality.
    • Scattering media pose significant challenges for current OCT techniques.

    Purpose of the Study:

    • To demonstrate digital correction of sample defocus in TD-FF-OCT within scattering media.
    • To investigate the effectiveness of digital defocus correction over a wide range.
    • To enhance the achievable imaging depth and image quality of TD-FF-OCT.

    Main Methods:

    • Matched optical path lengths in sample and reference arms of the interferometer.
    • Implementation of digital signal processing for defocus compensation.
    • Testing the digital correction method on both reflective and scattering samples.

    Main Results:

    • Digital defocus correction successfully compensated for sample defocus in highly scattering media.
    • The technique effectively corrected up to 1 mm of defocus.
    • Image quality degradation due to defocus was significantly mitigated.

    Conclusions:

    • Digital defocus correction is a viable method to overcome limitations in TD-FF-OCT.
    • This approach extends the practical imaging depth and improves image fidelity in scattering biological tissues.
    • The technique holds promise for advanced biomedical imaging applications.