Factors Influencing Integration and Usability of Model-Informed Precision Dosing Software in the Intensive Care Unit

Area of Science:

• Pharmacology
• Critical Care Medicine
• Health Informatics

Background:

• Optimizing antimicrobial dosing in critically ill patients presents significant challenges.
• Model-informed precision dosing (MIPD) software offers a potential solution for personalized antimicrobial therapy.
• Current adoption of MIPD software in intensive care units (ICUs) remains limited.

Purpose of the Study:

• To evaluate the perceived usability of MIPD software among ICU clinicians.
• To identify barriers and enablers for implementing MIPD software within the ICU setting.

Main Methods:

• A mixed-method study involving clinicians (pharmacists and medical staff) who used MIPD software.
• Quantitative data collection using the Post-study System Usability Questionnaire (PSSUQ) and Technology Acceptance Model 2 (TAM2).
• Qualitative data collection through semistructured interviews, analyzed using the framework approach.

Main Results:

• Clinicians rated the MIPD software usability below established reference norms.
• Software acceptance was generally favorable, with the exception of image-related domains.
• Key enablers for integration included accessible data entry and clear recommendations; barriers included rigid data entry and non-conforming recommendations.

Conclusions:

• The MIPD software demonstrated usability scores below the threshold for good usability.
• Availability of specialist clinician support was a crucial factor for participants.
• Rigid data entry systems were identified as a significant deterrent to software adoption.