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Fibrinogen: Structure, abnormalities and laboratory assays

Berrak Güven1, Murat Can1

  • 1Department of Clinical Biochemistry, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.

Advances in Clinical Chemistry
|May 18, 2024
PubMed

Fibrinogen is the primary precursor protein for the fibrin clot, which is the final target of blood clotting. It is also an acute phase reactant that can vary under physiologic and inflammatory conditions. Disorders in fibrinogen concentration and/or function have been variably linked to the risk of bleeding and/or thrombosis. Fibrinogen assays are commonly used in the management of bleeding as well as the treatment of thrombosis. This chapter examines the structure of fibrinogen, its role in hemostasis as well as in bleeding abnormalities and measurement thereof with respect to clinical management.

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