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Updated: Jun 26, 2025

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
Published on: March 28, 2025
Progress on the function of Mycobacterium T7SS (ESX) secretion system
Zhi-Yong Jiang1, Jian-Ping Xie1
1Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China.
Abstract:
Mycobacterium infection can affect the host's immune function by secreting extracellular effector proteins. ESX (or type VII) system plays an important role in the secretion of effector proteins. ESX system is the protein export system in mycobacteria and many actinomycetes. However, how ESX system secretes and underlying mechanism of action remain unclear. In this review, we introduce the components, function, classification of ESX system and the process of substrates transfer to the peripheral space via this system, and discuss the roles of ESX system in antibiotics resistance, persistence, host-phage interaction, new drug targets. We hope to provide insights into the discovery of new drugs and vaccine antigens for tuberculosis.
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