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Updated: Jun 26, 2025
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Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic Microscopy
Published on: September 16, 2022
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Neurophotonics: a comprehensive review, current challenges and future trends.
Beatriz Jacinto Barros1, João P S Cunha1,2
1INESC TEC - Institute for Systems and Computer Engineering, Technology and Science, Porto, Portugal.
Frontiers in Neuroscience
|May 20, 2024
Summary
Neurophotonics advances offer new ways to study the brain. This review details innovations in optogenetics, neural interfaces, and therapeutics over the past decade, highlighting future challenges and potential.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Optics
Background:
- The human brain's complexity presents significant challenges in understanding neural mechanisms and disease.
- Advancements in neuroscience and therapeutics necessitate innovative technologies for studying neural interactions.
Purpose of the Study:
- To provide an overview of neurophotonic approaches developed over the last 10 years.
- To analyze key technological advancements and identify challenges in the field of neurophotonics.
Main Methods:
- A multi-source literature analysis using PRISMA guidelines.
- Systematic review of 56 selected papers from Scopus, PubMed, and Web of Science databases.
- Categorization of research into six main areas: optogenetics, neural interfaces, therapeutics, imaging, remote operations, and microfluidics.
Main Results:
- Identified six key areas of applied neurophotonic research.
- Discussed photonic principles, neuroscience applications, and potential of selected technologies.
- Highlighted advancements in specificity, light delivery, multimodality, imaging, materials, and system design.
Conclusions:
- Neurophotonics has seen significant progress in understanding neural circuits and developing new therapies.
- Future innovation requires addressing challenges in light delivery, physical constraints, and data management for effective translation.
