The paucity of high-level evidence for therapy in pediatric cardiology

Emily Littman1, Diana Hsiao1, Kanekal S Gautham1,2

  • 1Department of Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.

PubMed

Insights

In 2021, most pediatric cardiology studies offered low scientific evidence. There is a critical need for more high-level evidence research in pediatric cardiology to improve clinical practice.

Area of Science:

  • Cardiology
  • Pediatrics
  • Evidence-Based Medicine

Background:

  • Clinical practice relies on high-quality evidence.
  • Assessing the evidence level in pediatric cardiology publications is crucial.

Purpose of the Study:

  • To classify publications in pediatric cardiology by evidence level in 2021.
  • To identify trends in study design and evidence quality.

Main Methods:

  • PubMed search for pediatric cardiology articles published in 2021.
  • Categorization of studies by evidence level (low, medium, high) based on study design.
  • Comparison of randomized control trials (RCTs) with neonatology and adult cardiology.

Main Results:

  • 731 studies were identified; 50.1% were low evidence, 44.2% medium, and 5.8% high.
  • Low-level evidence predominated across all cardiac disease types and treatments.
  • Most high-level evidence studies originated from the USA, China, and India.

Conclusions:

  • Pediatric cardiology research in 2021 was predominantly based on low-level evidence.
  • There is a significant need for more high-level evidence studies in pediatric cardiology.
  • Improving evidence quality is essential for advancing clinical practice in the field.
Abstract

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