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The paucity of high-level evidence for therapy in pediatric cardiology
Emily Littman1, Diana Hsiao1, Kanekal S Gautham1,2
1Department of Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.
Insights
In 2021, most pediatric cardiology studies offered low scientific evidence. There is a critical need for more high-level evidence research in pediatric cardiology to improve clinical practice.
Area of Science:
- Cardiology
- Pediatrics
- Evidence-Based Medicine
Background:
- Clinical practice relies on high-quality evidence.
- Assessing the evidence level in pediatric cardiology publications is crucial.
Purpose of the Study:
- To classify publications in pediatric cardiology by evidence level in 2021.
- To identify trends in study design and evidence quality.
Main Methods:
- PubMed search for pediatric cardiology articles published in 2021.
- Categorization of studies by evidence level (low, medium, high) based on study design.
- Comparison of randomized control trials (RCTs) with neonatology and adult cardiology.
Main Results:
- 731 studies were identified; 50.1% were low evidence, 44.2% medium, and 5.8% high.
- Low-level evidence predominated across all cardiac disease types and treatments.
- Most high-level evidence studies originated from the USA, China, and India.
Conclusions:
- Pediatric cardiology research in 2021 was predominantly based on low-level evidence.
- There is a significant need for more high-level evidence studies in pediatric cardiology.
- Improving evidence quality is essential for advancing clinical practice in the field.
Introduction:
Clinical practice should be based on the highest quality of evidence available. Therefore, we aimed to classify publications in the field of pediatric cardiology in the year 2021 based on the level of scientific evidence.
Materials And Methods:
A PubMed search was performed to identify pediatric cardiology articles published in the calendar year 2021. The abstract or manuscript of each study was reviewed. Each study was categorized as high, medium, or low level of evidence based on the study design. Disease investigated, treatment studied, and country of publication were recorded. Randomized control trials (RCTs) in similar fields of neonatology and adult cardiology were identified for comparison. Descriptive statistics were performed on the level of evidence, type of disease, country of publication, and therapeutic intervention.
Results:
In 2021, 731 studies were identified. A decrease in prevalence for the level of evidence as a function of low, medium, and high was found (50.1%, 44.2%, and 5.8%, respectively). A low level of evidence studies was the majority for all types of cardiac disease identified, including acquired heart disease, arrhythmias, congenital heart disease, and heart failure, and for treatment modalities, including circulatory support, defibrillator, percutaneous intervention, medicine, and surgery. In a subgroup analysis, most high-level evidence studies were from the USA (31%), followed by China (26.2%) and India (14.3%). Comparing RCTs, 21 RCTs were identified in pediatric cardiology compared to 178 in neonatology and 413 in adult ischemic heart disease.
Conclusions:
There is a great need for the conduct of studies that offer a high level of evidence in the discipline of pediatric cardiology.
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