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Diesel Particulate Matter Permeation into Normal Human Skin and Intervention Using a Topical Ceramide Formulation.

Kyong-Oh Shin1,2, Kenya Ishida3, Hisashi Mihara3

  • 1Department of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea.

Skin Pharmacology and Physiology
|May 20, 2024
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Summary
This summary is machine-generated.

Diesel particulate matter (DPM) contains toxic polycyclic aromatic hydrocarbons (PAHs) that can penetrate skin. A specialized topical formulation effectively blocks DPM and PAH skin permeation, protecting even healthy skin.

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Area of Science:

  • Dermatology
  • Environmental Health
  • Toxicology

Background:

  • Diesel particulate matter (DPM) is a significant air pollutant, carrying toxic polycyclic aromatic hydrocarbons (PAHs).
  • Skin exposure to DPM is linked to various dermatological conditions and premature aging.
  • The skin's epidermal barrier normally limits DPM penetration, but its effectiveness against adsorbed toxins is not fully understood.

Purpose of the Study:

  • To investigate the permeation of PAHs adsorbed to DPM into human skin.
  • To evaluate the efficacy of a topical formulation in preventing DPM and PAH skin penetration.

Main Methods:

  • Utilized ex vivo organ-cultured human skin exposed to DPM.
  • Quantified specific PAHs (2-methylnaphthalene, triphenylene, benzo(a)pyrene) in skin layers using liquid chromatography-tandem mass spectrometry.
  • Assessed the impact of a topical formulation on PAH permeation.

Main Results:

  • PAHs adsorbed to DPM were detected in both the epidermis and dermis of human skin.
  • PAH levels were significantly higher in the epidermis compared to the dermis.
  • A topical formulation forming uniform membrane structures demonstrably reduced PAH permeation into the skin.

Conclusions:

  • Toxic compounds adsorbed by DPM can penetrate intact skin, posing risks.
  • Individuals with compromised skin barriers (e.g., atopic dermatitis, psoriasis) are more susceptible to DPM-related damage.
  • Targeted topical formulations can create a protective barrier against DPM and adsorbed toxins.