Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease...

Area of Science:

• Cardiovascular Research
• Biomarkers
• Endothelial Function

Background:

• Coronary heart disease (CHD) poses a significant health challenge for women.
• Understanding novel biomarkers for CHD risk and prognosis is crucial.

Purpose of the Study:

• To investigate the association between serum microRNA-18a (miR-18a) levels and endothelial function in female patients with CHD.
• To evaluate the predictive value of miR-18a for CHD occurrence and prognosis.

Main Methods:

• 160 female patients with chest pain were categorized into CHD and non-CHD groups via coronary angiography.
• Serum miR-18a, endothelial function markers (nitric oxide, endothelin-1, flow-mediated dilation), and clinical data were analyzed.
• Correlation and receiver operating characteristic (ROC) curve analyses were performed.

Main Results:

• CHD patients exhibited significantly higher serum miR-18a and endothelin-1, with lower nitric oxide and flow-mediated dilation compared to non-CHD controls.
• Serum miR-18a positively correlated with endothelin-1 and negatively with nitric oxide and flow-mediated dilation.
• miR-18a demonstrated high predictive value for CHD occurrence (AUC = 0.878) and was associated with poorer prognosis.

Conclusions:

• Elevated serum miR-18a is prevalent in female CHD patients and is linked to impaired endothelial function.
• Increased serum miR-18a serves as a risk factor for major adverse cardiovascular events (MACE) and can predict CHD occurrence in women.