Related Experiment Video
Updated: Jun 25, 2025

09:51
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
12.4K
Precision nanoscale patterning of TLR ligands for improved cancer immunotherapy
Chung Yi Tseng1, Farshad Murtada1, Leo Y T Chou1
1Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Cell Reports Methods
|May 21, 2024
Abstract
None:
In a recent issue of Nature Nanotechnology, Zeng et al. report that arraying immuno-stimulatory CpG molecules with specific nanoscale spacing on DNA origami nanoparticles enhanced Th1-polarized immune responses. These results highlight spatial presentation of adjuvants as a design strategy to optimize cancer vaccine efficacy, safety, and tolerability.

