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Antioxidant Supplementation for Erectile Dysfunction: Systematic Review and Meta-Analysis of Double-Blind,
Ranjith Ramasamy1, Samir Bhattacharyya2, Taylor P Kohn1
1Desai Sethi Urology Institute, University of Miami, Miami, FL, USA.
The World Journal of Men'S Health
|May 21, 2024
Summary
Antioxidant supplements safely improve erectile function (ED) in men, especially those with severe symptoms. This meta-analysis found significant benefits with minimal side effects compared to placebo.
Area of Science:
- Urology
- Nutritional Science
- Clinical Research
Background:
- Erectile dysfunction (ED) affects a significant number of men.
- Current treatments for ED have limitations.
- Antioxidants are being explored for their potential therapeutic benefits in ED.
Purpose of the Study:
- To evaluate the efficacy and safety of oral antioxidant supplementation for treating erectile dysfunction (ED).
Main Methods:
- Systematic search of MEDLINE, Embase, and Cochrane Library for relevant randomized controlled trials.
- Inclusion of double-blind, placebo-controlled trials involving men with ED.
- Meta-analysis using random-effects models to compare International Index of Erectile Function-Erectile Function domain (IIEF-EF) scores and side effect frequencies.
Main Results:
- Included 23 trials with 1,583 men; median treatment duration was 12 weeks.
- Antioxidant supplementation significantly improved IIEF-EF scores by 5.5 points compared to placebo (p<0.001).
- Greater treatment benefits were observed in men with more severe ED (p<0.001); side effects were infrequent and comparable to placebo.
Conclusions:
- Antioxidant supplementation is a safe and effective treatment for improving erectile function in men with ED.
- The benefits are more pronounced in individuals with more severe erectile dysfunction.
- Further research is needed to determine long-term efficacy and optimal product/dosing strategies.
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