Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polymer Classification: Architecture01:14

Polymer Classification: Architecture

2.9K
Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
2.9K
Bioplastics01:27

Bioplastics

70
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
70

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly Programmable Liquid Crystalline Polyurethane/MXene Hybrids for Large-Strain, High-Work-Capacity Artificial Muscles.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Bone Marrow-Derived Macrophages' Response to Anisotropic Forces through Distinct Sensing and Transduction Pathways.

ACS applied materials & interfaces·2026
Same author

Topology-Engineered Hyperbranched Zwitterionic Polymer Enabling Robust Hydration Lubrication in Osteoarthritic Joints.

Biomacromolecules·2026
Same author

One-Pot Preparation of an Antioxidant, Anti-Inflammatory, and Analgesic Hydrogel for Oral Mucosal Lesions.

ACS applied materials & interfaces·2025
Same author

Injectable pH-Responsive Hydrogel Adapted to Gingival Crevicular Fluid Microenvironment for Periodontitis Therapy.

ACS applied materials & interfaces·2025
Same author

Fabricating Remote-Controllable Dynamic Ionomer/CNT Networks via Cation-π Interaction for Multi-Responsive Shape Memory and Self-Healing Capacities.

ACS applied materials & interfaces·2025

Related Experiment Video

Updated: May 5, 2026

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

13.4K

Engineering Biodegradable Polyurethanes with Precisely Controlled Hierarchical Structures to Access Shape Memory

Ling Yuan1, Li Xiao2, Jie Zhang1

  • 1The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610064, China.

Biomacromolecules
|May 23, 2024
PubMed
Summary

This study developed a novel biodegradable polyurethane (PPDO-PLC) with tunable shape memory effects (SMEs) and enhanced bioactivity. The material offers a promising solution for medical implants, balancing performance, degradation, and cellular interaction.

More Related Videos

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.6K
Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

12.7K

Related Experiment Videos

Last Updated: May 5, 2026

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

13.4K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.6K
Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

12.7K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Biodegradable polymers with shape memory effects (SMEs) are crucial for temporary medical devices, but balancing properties like mechanical performance, degradation, and bioactivity is challenging.
  • Existing materials often require secondary surgeries for removal, increasing patient burden.
  • Developing advanced biodegradable materials with tailored properties is essential for improved medical interventions.

Purpose of the Study:

  • To develop a versatile biodegradable polyurethane (PPDO-PLC) with tunable hierarchical structures for optimized shape memory effects (SMEs) and bioactivity.
  • To address the challenge of balancing biodegradability, mechanical performance, degradation rate, and bioactivity in a single material.
  • To create a material suitable for minimally invasive procedures and subsequent degradation without removal surgery.

Main Methods:

  • Developed a biodegradable polyurethane (PPDO-PLC) through precise chain segment control, involving copolymerization of l-lactide, ε-caprolactone, and poly(p-dioxanone).
  • Engineered tunable hierarchical structures and uniform microphase-separation morphology to achieve robust SMEs.
  • Created rough porous surface structures in alkaline environments to enhance cellular interactions.

Main Results:

  • The synthesized PPDO-PLC exhibited tunable glass transition temperature (Tg) near body temperature and robust SMEs.
  • Alkaline treatment resulted in rough porous surfaces that significantly enhanced cell adhesion, proliferation, and osteogenic differentiation.
  • The material demonstrated a balance between biodegradability, SMEs, 3D printability, and bioactivity.

Conclusions:

  • The developed PPDO-PLC offers a promising platform for advanced medical applications requiring shape memory and enhanced bioactivity.
  • Hierarchical structure regulation is an effective strategy for balancing multiple material properties in biodegradable polymers.
  • This approach provides a pathway for designing next-generation biomaterials for tissue engineering and regenerative medicine.