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CD8 is down(regulated) for tolerance

Noé Rodríguez-Rodríguez1, Florencia Rosetti2, José C Crispín3

  • 1Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.

Trends in Immunology
|May 23, 2024
PubMed

Activated CD8+ T cells directly kill target cells. Therefore, the regulation of their function is central to avoiding immunopathology. Mechanisms that curb effector functions in CD4+ and CD8+ T cells are mostly shared, yet important differences occur. Here, we focus on the control of CD8+ T cell activity and discuss the importance of a poorly understood aspect of tolerance that directly impairs engagement of target cells: the downregulation of CD8. We contextualize this process and propose that it represents a key element during CD8+ T cell modulation.

Keywords:
CD8double negative T celltolerance

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