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Updated: Jun 25, 2025

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Defeating MYC with drug combinations or dual-targeting drugs

Philip E Thompson1, Jake Shortt2

  • 1Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Trends in Pharmacological Sciences
|May 23, 2024
PubMed

Insights

Developing combination therapies or dual-acting drugs targeting MYC proteins is crucial for overcoming challenges in blocking MYC-driven cancers. These approaches may offer enhanced efficacy and reduced resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • The MYC family of proteins are critical drivers of numerous cancers.
  • Targeting MYC has been a long-standing goal in cancer drug discovery.
  • Current MYC-targeted therapies have faced significant challenges and limited success.

Purpose of the Study:

  • To review prominent MYC-related targets for cancer therapy.
  • To highlight existing combination and dual-target approaches against MYC.
  • To explore the challenges associated with developing these advanced therapeutic strategies.

Main Methods:

  • Literature review of MYC-related targets.
  • Analysis of combination and dual-target drug development strategies.
  • Examination of drug development challenges for MYC-targeted therapies.

Main Results:

  • MYC proteins are key targets in cancer drug discovery.
  • Combination or dual-acting drugs offer potential for synergistic effects.
  • These approaches may reduce side effects and combat drug resistance.

Conclusions:

  • Developing novel therapeutic strategies targeting MYC is essential.
  • Combination and dual-target approaches show promise for MYC-driven cancers.
  • Overcoming drug development hurdles is critical for clinical success.
Keywords:
MYCanti-cancer drug discoverycombination therapiesdual target drugs

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