Triglyceride-Glucose Index Associated with Future Renal Function Decline in the General Population
Daisuke Yoshida1, Shota Ikeda1,2, Keisuke Shinohara3
1Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Journal of General Internal Medicine
|May 23, 2024
Summary
A high triglyceride-glucose (TyG) index is linked to a greater risk of future kidney function decline in the general population. This marker can help identify individuals needing closer monitoring for renal health.
Area of Science:
- Nephrology
- Endocrinology
- Public Health
Background:
- The triglyceride-glucose (TyG) index is a recognized marker for insulin resistance.
- Its association with future renal function decline in the general population is not well-established.
Purpose of the Study:
- To investigate the relationship between the TyG index and the future decline of renal function.
- To assess the TyG index's utility in identifying individuals at risk for kidney function decline.
Main Methods:
- Retrospective longitudinal observational cohort study.
- Analysis of data from 10,758 individuals from a population-based health checkup.
- Renal function decline defined as a ≥25% decrease in estimated glomerular filtration rate (eGFR).
Main Results:
- Individuals with a high TyG index (≥8.76) had a significantly higher risk of future renal function decline (HR 2.25).
- The association remained consistent across various subgroups, including those with hypertension, diabetes, or dyslipidemia.
- Incidence rates of renal function decline were higher in the high TyG index group (0.69 per 100 person-years) compared to the low TyG index group (0.31 per 100 person-years).
Conclusions:
- A high TyG index is associated with an increased risk of future renal function decline in the general population.
- The TyG index can serve as a valuable tool for risk stratification of renal function decline during health checkups.
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