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Related Concept Videos

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Updated: May 5, 2026

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Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical

Xianli Wang1,2,3, Cheng Wang1,2, Chenglin Chu1,2

  • 1School of Materials Science and Engineering, Southeast University, Jiangning, Nanjing, 211189, Jiangsu, China.

Bioactive Materials
|May 24, 2024
PubMed
Summary

This review explores biodegradable Mg/polymer composites (BMPCs) for biomedical uses. Combining magnesium and polymers offers enhanced mechanical properties and tailored degradation rates for better tissue repair.

Keywords:
BiodegradationInterfaceMechanical propertyStimuli-responsivenessTissue engineering

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Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Tissue Engineering

Background:

  • Magnesium (Mg) and biodegradable polymers are promising for biomedical applications.
  • Challenges include matching degradation rates with tissue repair and managing pH changes during degradation.
  • Combining Mg and polymers in biodegradable Mg/polymer composites (BMPCs) aims to overcome these limitations.

Purpose of the Study:

  • To systematically review the design, manufacturing, mechanical properties, degradation behavior, and biological effects of BMPCs.
  • To highlight the structure-function relationships and degradation influencing factors.
  • To discuss the interplay of components and biological functions for advanced biomaterials.

Main Methods:

  • Comprehensive literature review on BMPCs.
  • Analysis of design concepts and manufacturing strategies.
  • Discussion of structure-property relationships, degradation kinetics, and biological responses.

Main Results:

  • High-strength BMPCs can be designed and manufactured by controlling microstructure.
  • Degradation rates are influenced by both internal (composition) and external (environment) factors.
  • Understanding component interactions and biological functions is crucial for stimuli-responsive platforms.

Conclusions:

  • BMPCs offer a promising approach to address the limitations of individual biodegradable materials.
  • Systematic understanding of BMPC behavior is essential for optimizing their performance in tissue repair.
  • This review provides insights for the future clinical application of structure-function integrated biomaterials.