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Depletion and Reconstitution of Macrophages in Mice
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Macrophage Functions in Psoriasis: Lessons from Mouse Models.

Katarzyna Nazimek1, Krzysztof Bryniarski1

  • 1Department of Immunology, Jagiellonian University Medical College, 31-121 Krakow, Poland.

International Journal of Molecular Sciences
|May 25, 2024
PubMed
Summary

Macrophages play dual roles in psoriasis, either triggering or ameliorating inflammation. Understanding these skin-resident immune cells offers potential for novel psoriasis therapies.

Keywords:
autoimmunitybiologicsimiquimodmacrophagesmodern dermatological treatmentmouse modelspsoriasiform dermatitispsoriasisrodent disease modelsskin diseases

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Area of Science:

  • Immunology
  • Dermatology
  • Autoimmune diseases

Background:

  • Psoriasis is a complex systemic autoimmune/autoinflammatory disease.
  • Skin-resident macrophages, including Langerhans cells and dermal macrophages, are key immune players.
  • These macrophages exhibit phenotypic plasticity, influencing tissue homeostasis and immunity.

Purpose of the Study:

  • To review current knowledge on the multifaceted roles of macrophages in psoriasis.
  • To highlight macrophages as potential therapeutic targets for psoriasis treatment.
  • To identify future research directions for understanding macrophage function in this disease.

Main Methods:

  • Review of existing literature on macrophages in psoriasis.
  • Analysis of immunological and homeostatic functions of skin macrophages.
  • Exploration of therapeutic strategies targeting macrophages.

Main Results:

  • Macrophages and Langerhans cells can both initiate and resolve psoriatic inflammation.
  • Their dual role is dependent on their activation state and microenvironmental cues.
  • Macrophages represent promising targets for innovative psoriasis treatments.

Conclusions:

  • Macrophages are critical regulators of psoriatic inflammation, exhibiting context-dependent pro- and anti-inflammatory activities.
  • Targeting macrophage phenotypes offers a promising avenue for developing effective psoriasis therapies.
  • Further research is needed to fully elucidate macrophage functions and harness their therapeutic potential in psoriasis.