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A Color-Detectable Vitamin C Controlled-Release System Fabricated Using Electrospinning.

Min Jae Shin1

  • 1Department of Chemical and Biological Engineering, Andong National University, Andong 36729, Gyeongbuk, Republic of Korea.

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|May 25, 2024
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Summary

This study presents a novel vitamin C delivery system using coaxial microfibers. The system visually signals vitamin C release through a color change, enabling real-time monitoring.

Keywords:
controlled-release systemelectrospinningpolydiacetylenevitamin C

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Controlled drug delivery systems are crucial for therapeutic efficacy.
  • Visual indicators for release kinetics can enhance monitoring capabilities.
  • Vitamin C (ascorbic acid) plays vital roles in biological systems, necessitating accurate delivery and tracking.

Purpose of the Study:

  • To develop a vitamin C controlled-release system with an integrated visual detection mechanism.
  • To engineer coaxial microfibers capable of releasing vitamin C and changing color upon release.
  • To establish a method for regulating vitamin C release rates through material design.

Main Methods:

  • Coaxial electrospinning was employed to fabricate microfibers with distinct core and shell compositions.
  • The core comprised poly(ethylene oxide) (PEO) loaded with vitamin C.
  • The shell consisted of polycaprolactone (PCL) incorporating polydiacetylene (PDA) for colorimetric sensing.

Main Results:

  • The coaxial microfiber system successfully encapsulated and controlled the release of vitamin C.
  • The polydiacetylene (PDA) within the PCL shell exhibited a color transition from blue to red as vitamin C permeated the shell.
  • Varying the polycaprolactone (PCL) shell thickness allowed for modulation of the vitamin C release rate.

Conclusions:

  • A novel, visually trackable vitamin C controlled-release system was successfully developed using coaxial electrospinning.
  • The system offers a promising platform for real-time monitoring of vitamin C release.
  • Potential applications include medical devices and diagnostic tools requiring immediate detection of vitamin C levels.