Natural 3,4-Dihydro-2(1H)-quinolinones - part III: biological activities

Natural products have played a crucial role in drug discovery, but their development is hindered by challenges such as inadequate availability and complex synthesis methods. However, both natural and synthetic compounds that have the core structure of 3,4-dihydro-2(1H)-quinolinone, also known as 2-oxo-1,2,3,4-tetrahydroquinoline (2O-THQ), display a diverse array of effects in both central and peripheral tissues, with some showing therapeutic potential in treating various disorders. Despite the significance of this family of compounds, the current literature lacks comprehensive coverage of their biological functions. This article aims to address this gap by extensively reviewing the biological activities of 2O-THQ alkaloids from diverse organisms and exploring their potential to serve as a source of innovative bioactive natural products.