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Adipokines in pregnancy
Monika Dawid1, Karolina Pich1, Ewa Mlyczyńska1
1Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Krakow, Poland; Doctoral School of Exact and Natural Sciences, Jagiellonian University in Krakow, Krakow, Poland.
Advances in Clinical Chemistry
|May 26, 2024
Summary
Pregnancy success relies on hormonal balance, but obesity disrupts adipokine secretion, impacting placental function and offspring health. This review examines adipokines in pregnancy, from normal to complicated conditions like gestational diabetes.
Area of Science:
- Reproductive biology and endocrinology.
- Maternal-fetal interface and placental development.
Background:
- Reproductive success involves a complex sequence of events, including fertilization, implantation, placentation, and intricate cellular processes.
- Pregnancy maintenance is regulated by maternal factors, genetics, proteins, and hormones, with white adipose tissue secreting key adipokines.
- Obesity disrupts adipokine synthesis and secretion, significantly altering placental function and pregnancy outcomes.
Purpose of the Study:
- To summarize current knowledge on adipokine levels and their roles within the placenta.
- To explore adipokine involvement in both physiological and pathological pregnancy conditions.
- To consider findings across humans, domestic animals, and rodents for comparative insights.
Main Methods:
- Review and synthesis of existing scientific literature.
- Analysis of studies investigating adipokine profiles in placental tissues.
- Examination of data from physiological and pathological pregnancy models.
Main Results:
- Adipokines play critical roles in regulating placental development and function.
- Altered adipokine levels are associated with pregnancy complications such as gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction.
- Obesity-induced changes in adipokines significantly impact the maternal-placental environment.
Conclusions:
- Adipokines are crucial mediators in maintaining pregnancy homeostasis and placental health.
- Dysregulation of adipokines due to obesity contributes to adverse pregnancy outcomes.
- Further research into adipokine function is vital for understanding and managing pregnancy complications.
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