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Sphincter of oddi dysfunction induced by ketamine: A case report
Nava Raj Sharma1, Arjun Basnet2, Saral Lamichhane3
1Manipal College of Medical Sciences Pokhara Nepal.
Chronic ketamine abuse can cause sphincter of Oddi dysfunction (SOD), leading to liver and pancreas damage. Early recognition of ketamine use is key to preventing severe hepatobiliary complications.
Area of Science:
- Gastroenterology and Hepatology
- Toxicology
- Substance Abuse Research
Background:
- Ketamine is a widely abused recreational drug known for its euphoric effects.
- Ketamine abuse is linked to significant hepatobiliary complications, including cholestasis and biliary sepsis.
Observation:
- A case study of a 29-year-old female presenting with upper abdominal pain due to sphincter of Oddi dysfunction (SOD).
- The patient's SOD was a direct result of chronic ketamine use.
Findings:
- Ketamine induces SOD through the activation of muscarinic receptors in the sphincter of Oddi.
- SOD can lead to obstruction or dysfunction of the bile and pancreatic ducts, causing pain and potential organ damage.
Implications:
- Identifying a history of substance abuse, particularly ketamine, is critical for diagnosing ketamine-induced SOD.
- Early diagnosis and intervention are essential to prevent irreversible liver and pancreas injury.
- This highlights the importance of considering drug abuse in the differential diagnosis of hepatobiliary disorders.
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