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Updated: Jun 25, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Synthesis of thioesters using an electrochemical three-component reaction involving elemental sulfur
Gongbo Liu1, Shuoyu Xu1, Yangyang Yue1
1Cancer Hospital of Dalian University of Technology, School of Chemistry, School of Chemical Engineering, Dalian, 116024, P. R. China. wzsong@dlut.edu.cn.
Abstract:
An electrochemical three-component reaction involving elemental sulfur is disclosed for achieving a metal-free, oxidant-free synthesis of thioesters in a high atom-economical, step-economical and chemoselective manner. A mechanistic investigation indicates that the use of elemental sulfur to trap acyl radical derived from radical umpolung of α-keto acid with an electrochemical design can efficiently generate a carbonyl thiyl radical, which can further be captured by diazoalkane to afford various thioesters.
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