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Solvents

Solvents

A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
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Related Experiment Video

Updated: Jun 25, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile

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Published on: October 30, 2018

Total Synthesis of (±)-Simonsol C.

Jia-Jun Sui¹, Kai Wang¹, Song-Juan Luo¹

¹School of Chemistry and Environment, National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650504, China.

The Journal of Organic Chemistry

|May 28, 2024

Summary

Total synthesis of simonsol C was achieved using postdearomatization transformations. This novel method efficiently constructs the benzofuran skeleton and creates allyl-containing quaternary carbons.

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Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

Simonsol C is a complex natural product.
Efficient synthetic routes are crucial for accessing such molecules.

Purpose of the Study:

To achieve the total synthesis of simonsol C.
To develop novel postdearomatization transformations for constructing complex skeletons.

Main Methods:

The synthesis involved dearomatization followed by Zn/AcOH reduction to introduce an allyl group.
Oxo-Michael addition was employed to build the 6/5/6 benzofuran skeleton.

Main Results:

Successful total synthesis of simonsol C.
Efficient construction of the benzofuran core structure.
A novel method for synthesizing allyl-containing quaternary carbon atoms was established.

Conclusions:

The developed methodology provides a straightforward route to simonsol C.
This approach offers a new strategy for creating complex molecular architectures with quaternary centers.