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Related Experiment Video

Updated: Jun 25, 2025

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
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PREVALENCE OF PRETERM DELIVERY AMONG WOMEN WHO RECEIVE PROGESTERONE SUPPLEMENTATION DURING PREGNANCY: CROSS-SECTIONAL

Ch Maarof1, A Dauod1, R Dunham1

  • 1Kurdistan Family Medicine Board Centre, Duhok, Kurdistan Region, Iraq.

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Preterm birth (PTB) occurred in 12% of women. Progesterone use did not significantly impact PTB rates, suggesting its prescription may be outside established indications. Further research is needed.

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Pharmacology

Background:

  • Preterm birth (PTB) is a major cause of perinatal morbidity and mortality.
  • Progesterone supplementation is used in pregnancy, but its effectiveness varies.
  • Understanding progesterone prescription patterns and PTB rates is crucial.

Purpose of the Study:

  • To assess progesterone prescription prevalence and routes of administration.
  • To determine the prevalence of PTB and delivery routes.
  • To compare PTB rates in women who received progesterone versus those who did not.

Main Methods:

  • An observational, cross-sectional study of 300 postpartum women in Duhok.
  • Interviews conducted with women up to 1 year postpartum.
  • Data collected on pregnancy history, risk factors, complications, and progesterone use.

Main Results:

  • The overall PTB rate was 12%.
  • 38% of women reported progesterone therapy, with parenteral and multiple routes being common.
  • No statistically significant difference in PTB rates was found between women who received progesterone and those who did not (P=0.08).

Conclusions:

  • Progesterone prescription prevalence was substantial, but its use was not significantly associated with reduced PTB rates in this cohort.
  • The lack of significant difference may be due to progesterone use outside of established indications, such as short cervix.
  • Further randomized controlled trials are necessary to clarify the role of progesterone supplementation in preventing PTB.