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Related Experiment Video

Updated: Jun 25, 2025

Behavioral Assessment of the Aging Mouse Vestibular System
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Vestibulo-Ocular Reflex in the Aging Population.

Basak Mutlu1, Sidika Cesur1, Ahmet Mutlu2,3

  • 1Department of Audiology, Istanbul Medeniyet University Faculty of Health Sciences, Istanbul, Türkiye.

Sisli Etfal Hastanesi Tip Bulteni
|May 29, 2024
PubMed
Summary
This summary is machine-generated.

Vestibulo-ocular reflex (VOR) in healthy older adults shows subtle age-related changes after 70. Corrective saccades, not just VOR gain, may better reveal these aging vestibular system changes.

Keywords:
Agingcorrective saccadesvestibulo-ocular reflexvideo head impulse test

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Area of Science:

  • Otolaryngology
  • Neuroscience
  • Gerontology

Background:

  • The vestibulo-ocular reflex (VOR) is crucial for gaze stability.
  • Age-related changes in the vestibular system can impact balance and vision.
  • Understanding these changes in healthy older adults is essential for identifying early signs of vestibular dysfunction.

Purpose of the Study:

  • To evaluate the vestibulo-ocular reflex (VOR) in individuals over 60 without diagnosed vestibular pathology.
  • To investigate age-related differences in VOR function between the 7th and 8th decades of life.
  • To explore the correlation between VOR gains, corrective saccades, and age.

Main Methods:

  • Bilateral six-semicircular canal video head impulse test (vHIT) was performed.
  • Dizziness Handicap Inventory and European Evaluation of Vertigo scales were administered.
  • 103 healthy participants (mean age 69.35 ± 7.41 years) were analyzed, divided into 7th decade (64.32±3.12) and 8th decade and older (76.11±5.93) groups.

Main Results:

  • No significant differences in VOR gains were found between the 7th and 8th decade groups for any semicircular canal.
  • In the 8th decade and older group, corrective saccades showed a moderate positive correlation with VOR gains in the right lateral and left posterior semicircular canals.
  • A weak negative correlation was observed between age and left lateral semicircular canal VOR gain in the 8th decade and older group.

Conclusions:

  • Age-related changes in the vestibular system become apparent after 70 years of age.
  • Corrective saccade findings may be more sensitive than VOR gains in detecting age-related VOR alterations.
  • vHIT is a valuable tool for assessing VOR function and age-related changes in older adults.