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Changes in M6A methylation: A key factor in the vicious cycle of flora -gut aging

Menglu Ding1, Junbin Yan1, Yuxuan Chen1

  • 1The Second Affiliated Hospital of Zhejiang Chinese Medical University (The Xin Hua Hospital of Zhejiang Province), Hangzhou, PR China; Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310000, PR China.

Ageing Research Reviews
|May 31, 2024
PubMed

Insights

Epigenetic modifications, specifically N6-methyladenosine (m6A) methylation, are crucial in gut aging and intestinal flora imbalance. Targeting m6A methylation may reverse gut aging and restore microbial balance.

Area of Science:

  • Gerontology
  • Microbiology
  • Epigenetics

Background:

  • Aging impacts the gastrointestinal tract, worsening age-related diseases.
  • Intestinal flora imbalance is linked to gut aging, but mechanisms are unclear.
  • Epigenetic modifications, like m6A methylation, are key drivers of aging and gut aging.

Purpose of the Study:

  • To explore the role of N6-methyladenosine (m6A) methylation in the gut aging process.
  • To investigate the connection between m6A methylation, gut aging, and intestinal flora.
  • To propose m6A methylation as a therapeutic target for gut aging.

Main Methods:

  • Literature review on aging, gut microbiota, and m6A methylation.
  • Analysis of existing research linking epigenetic modifications to gut health.
  • Synthesis of current understanding of m6A methylation's role in aging.

Main Results:

  • m6A methylation is vital for maintaining intestinal microbial balance.
  • m6A methylation is implicated in the detrimental cycle of gut aging and dysbiosis.
  • Targeting m6A methylation presents a potential strategy to mitigate gut aging.

Conclusions:

  • m6A methylation is a critical factor at the intersection of gut aging and intestinal flora.
  • Modulating m6A methylation could offer a novel approach to attenuate or reverse gut aging.
  • Further research into m6A-targeted therapies is warranted for age-related gastrointestinal decline.
Keywords:
DysbiosisFlora imbalanceGut agingIntestinal floraLow inflammationM6A methylation

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