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Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms
Peng-Yu Chen1, Minxue Shen2,3,4, Sui-Qing Cai1
1Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, People's Republic of China.
Journal of Inflammation Research
|June 3, 2024
Summary
Atopic dermatitis (AD) is common in older adults, linking skin health to aging. This review explores AD
Area of Science:
- Dermatology and Gerontology: Investigating the intersection of chronic inflammatory skin conditions and the aging process.
Background:
- Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease.
- The aging population is increasingly affected by AD, highlighting a critical public health concern.
Purpose of the Study:
- To review and summarize existing knowledge on the relationship between atopic dermatitis and aging.
- To discuss clinical observations of AD associations with aging-related diseases across multiple organ systems.
- To explore major theories underlying the correlation between AD and aging.
Main Methods:
- Literature review of clinical observations and major theories.
- Synthesis of data on associations between AD and aging-related diseases (endocrine, cardiovascular, neurological).
- Discussion of contributing factors: skin-mucosal barriers, systemic inflammation, genetics, and environmental influences.
Main Results:
- Atopic dermatitis is increasingly prevalent in the aging population.
- Observed associations exist between AD and aging-related diseases in endocrine, cardiovascular, and neurological systems.
- Key correlational theories involve barrier function, systemic inflammation, genetics, and environmental factors.
Conclusions:
- The association between atopic dermatitis and aging is significant from both population and basic science perspectives.
- Further research is needed to understand inflammation/allergy-aging dynamics.
- Timely and appropriate management of AD in elderly patients is crucial.
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