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Updated: Jun 24, 2025

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

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STAT3-induced lncRNA GNAS-AS1 accelerates keloid formation by mediating the miR-196a-5p/CXCL12/STAT3 axis in a

Yun Liu1, Teng-Xiao Ma1, Peng-Fei Fan1

  • 1Department of Plastic and cosmetic Surgery, Hainan General Hospital (Hainan Affifiliated Hospital of Hainan Medical University), Haikou, Hainan, China.

Experimental Dermatology
|June 6, 2024
PubMed
Summary

This study reveals a STAT3/GNAS-AS1/miR-196a-5p/CXCL12 feedback loop driving keloid progression by increasing fibroblast proliferation, migration, and extracellular matrix accumulation.

Keywords:
CXCL12GNAS‐AS1STAT3keloidmiR‐196a‐5p

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