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Related Concept Videos

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

418
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Routes of Drug Administration: Enteral01:18

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Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Shellac-based delivery systems for food bioactive compounds.

Xueqing Yao1, Yubo Zhu1, Huiyun Chen2

  • 1Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, China-Canada Joint Lab of Food Nutrition and Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.

International Journal of Biological Macromolecules
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

Shellac, a natural resin, offers unique properties for developing advanced delivery systems. These shellac-based platforms enhance the stability and bioavailability of food bioactive compounds.

Keywords:
Bioactive compoundsDelivery systemEncapsulationShellacTargeted release

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Area of Science:

  • Food Science
  • Materials Science
  • Biotechnology

Background:

  • Shellac is a natural resin with amphiphilic, pH-responsive, biocompatible, and biodegradable properties.
  • Increasing interest exists in utilizing shellac for controlled delivery of food bioactive compounds.
  • Shellac-based systems offer potential for improved functional food applications.

Purpose of the Study:

  • To review recent advances in shellac-based delivery systems for food bioactive compounds.
  • To investigate preparation methods, formation mechanisms, structures, and delivery performance of these systems.
  • To discuss deficiencies and challenges of current shellac-based delivery platforms.

Main Methods:

  • Review of literature on shellac-based delivery systems.
  • Analysis of various system types: nanoparticles, zein-shellac particles, hydrogels, nanofibers, and nanomicelles.
  • Evaluation of preparation, formation, structure, and delivery performance.

Main Results:

  • Shellac-based systems, including nanoparticles and hydrogels, improve bioactive compound stability and shelf-life.
  • These systems enable targeted release in the small intestine or colon.
  • Enhanced bioavailability of food bioactive compounds is achieved through shellac encapsulation.

Conclusions:

  • Shellac-based delivery systems show significant promise for functional food applications.
  • Further research into overcoming system deficiencies can lead to more efficient platforms.
  • These findings guide future development of advanced shellac-based delivery technologies.