Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epitope-Imprinted Polymers for Selective Recognition of Bacterial Proteins: From Design to Analytical Applications.

ACS measurement science au·2026
Same author

Fully 3D-Printed Sampling-to-Detection Electrochemical Platform for Point-of-Care Measurement of Salivary Uric Acid.

ACS measurement science au·2026
Same author

Toward Precision Electrochemical Sensing of CFTR Function in Cystic Fibrosis Models.

Analytical chemistry·2026
Same author

Dual Paper-Based Electrochemical Device for Multiplex Detection of Triple-Negative Breast Cancer miRNA Signatures.

Analytical chemistry·2026
Same author

Selenium-Bearing Conducting Polymer/Graphene Quantum Dot Hybrid for Enzyme Based Electrochemical Biosensor Targeting Tyrosinase Inhibition Via Rosmarinic Acid.

ChemistryOpen·2026
Same author

Multiplex Detection and Quantification of miRNAs in Drug Delivery Systems Using a Signal-Off Electrochemical Platform.

Analytical chemistry·2026
Same journal

Biodegradable Self-Powered Electrotherapy Patch for Integrated Smart Wound Management.

Analytical chemistry·2026
Same journal

Metabolite Fraction Libraries for Quantitative NMR Metabolomics.

Analytical chemistry·2026
Same journal

Self-Contained Lateral-Flow Microfluidic Bead-Based Assay for Rapid Quantification of Early-Stage Kidney Biomarkers.

Analytical chemistry·2026
Same journal

Overcoming the Debye Shielding Effect with Concave-Convex Structures for Sensitivity-Enhanced Thin-Film Transistors.

Analytical chemistry·2026
Same journal

Mode-Phase-Difference Photothermal Spectroscopy Assisted by a Bent Biconically Tapered Microfiber for Gas Sensing.

Analytical chemistry·2026
Same journal

Negative-Pressure-Actuated Microfluidics: A Dual-Mode Point-of-Care Sensor for Allergen-Specific IgE in Interstitial Fluid.

Analytical chemistry·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

15.7K

3D Paper-Based Origami Device for Programmable Multifold Analyte Preconcentration.

Panagiota M Kalligosfyri1, Stefano Cinti1,2

  • 1Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.

Analytical Chemistry
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

A new 3D paper-based origami device enables efficient multifold analyte preconcentration. This innovative tool enhances detection sensitivity without complex or time-consuming procedures, offering a versatile solution for analytical chemistry.

More Related Videos

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
07:53

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Published on: April 1, 2016

7.6K
Author Spotlight: Revolutionizing Microfluidics Through Microchannel Fabrication on Nanopaper
03:58

Author Spotlight: Revolutionizing Microfluidics Through Microchannel Fabrication on Nanopaper

Published on: October 6, 2023

1.5K

Related Experiment Videos

Last Updated: Jun 24, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

15.7K
Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
07:53

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Published on: April 1, 2016

7.6K
Author Spotlight: Revolutionizing Microfluidics Through Microchannel Fabrication on Nanopaper
03:58

Author Spotlight: Revolutionizing Microfluidics Through Microchannel Fabrication on Nanopaper

Published on: October 6, 2023

1.5K

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Preconcentration is crucial for enhancing analytical detection accuracy but often involves complex, time-consuming, or invasive methods.
  • Existing paper-based preconcentration techniques have limitations in balancing sensitivity enhancement with measurement time.

Purpose of the Study:

  • To introduce a novel 3D paper-based origami device for multifold analyte preconcentration.
  • To demonstrate enhanced sensitivity and reduced complexity compared to conventional and other paper-based methods.
  • To showcase the device's programmability and versatility for various analytes and matrices.

Main Methods:

  • Development of a novel 3D paper-based origami architecture leveraging the porous nature of paper.
  • Characterization of key parameters including disk size, number, unfolding time, and volume.
  • Application of the device for preconcentration and detection of mercury in tap water and glucose in sweat.

Main Results:

  • Achieved a 400% sensitivity enhancement for mercury detection in tap water.
  • Achieved a 300% sensitivity enhancement for glucose detection in sweat.
  • Demonstrated that the device increases sensitivity without sacrificing measurement time.

Conclusions:

  • The 3D paper-based origami device offers an innovative, cost-effective, and efficient solution for analyte preconcentration.
  • The device's design exploits intrinsic paper properties for improved analytical performance.
  • This universal tool has broad applicability across various analytical systems and fields.