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Updated: May 5, 2026
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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
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Allergic Rhinitis and Keratoconus: A Systematic Review and Meta-Analysis
Jui-En Lo1, Yen-Hsi Huang1, Neil Bhattacharyya2
1Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.
Summary
Patients with allergic rhinitis (AR) have a significantly higher risk of developing keratoconus. This meta-analysis confirms a strong association, suggesting closer monitoring for keratoconus in AR patients.
Area of Science:
- Ophthalmology
- Allergology
- Epidemiology
Background:
- The link between keratoconus and allergic diseases remains debated.
- Investigating the association between allergic rhinitis (AR) and keratoconus is crucial.
Approach:
- A systematic review and meta-analysis of observational studies was performed.
- Data from PubMed, Web of Science, and Cochrane Library were analyzed.
- Bivariate meta-analysis calculated the pooled odds ratio for keratoconus in AR patients.
Key Points:
- Seven studies with 775,574 participants were included.
- Patients with AR had a 1.71 times higher odds of keratoconus (P < .001).
- Sensitivity analysis confirmed the pooled adjusted odds ratio of 1.72 (P = .001).
Conclusions:
- Allergic rhinitis is significantly associated with increased odds of keratoconus.
- Further research is needed to establish causality.
- Early screening for keratoconus in AR patients is recommended.
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