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Generation of a human iPSC cell line (MUSIi017-A) from a donor with O negative blood type

Nittaya Jiamvoraphong1, Chanchao Lorthongpanich2, Phatchanat Klaihmon1

  • 1Siriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Stem Cell Research
|June 9, 2024
PubMed

The Rh-negative type O blood group (O Rh-) is considered a universal donor for emergency blood transfusions. Due to the constant shortage of this rare blood group, the production of blood cells from iPSCs derived from the O Rh- donor could potentially serve as a limitless blood source for transfusions. In this report, we establish a MUSIi017-A iPSC line from peripheral blood mononuclear cells of a healthy donor with the O Rh- blood group. The established iPSC line exhibited a normal karyotype, showed identical STR compared to donor peripheral blood mononuclear cells, and could differentiate to all three germ layers.

Keywords:
blood transfusioniPSCsuniversal donor

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