Related Experiment Video
Updated: Jun 24, 2025
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
The association between circulating leukocytes and inflammatory bowel disease: a two-sample Mendelian randomization
Li Tian1, Xiaobin Yang1, Yansen Zheng2
1Day Diagnosis and Treatment Department, The Sixth Medical Center of PLA General Hospital, Beijing, China.
Mendelian randomization analysis suggests certain leukocyte alterations causally influence inflammatory bowel disease (IBD) risk. Increased monocytes may decrease IBD risk, while neutrophils may increase it.
Area of Science:
- Genetics
- Immunology
- Gastroenterology
Background:
- Inflammatory bowel disease (IBD) is a chronic intestinal inflammation with uncertain links to circulating leukocytes.
- Observational studies suggest associations between leukocytes and IBD, but causal relationships require further investigation.
Purpose of the Study:
- To investigate the causal relationship between circulating leukocyte alterations and inflammatory bowel disease (IBD) risk using Mendelian randomization (MR).
Main Methods:
- Utilized genome-wide association study (GWAS) data for circulating leukocytes and IBD from the Blood Cell Consortium and IEU Qpen GWAS project.
- Employed inverse variance weighting (IVW) as the primary MR method, supplemented by sensitivity analyses for result validation.
Main Results:
- Increased monocyte counts, particularly CD14- CD16+ monocytes, showed a negative correlation with IBD risk.
- Elevated neutrophil counts were positively associated with the risk of IBD and ulcerative colitis.
- No causal link was found between basophil, eosinophil, or lymphocyte counts and IBD risk.
Conclusions:
- Established a causal relationship between specific circulating leukocytes and IBD risk, highlighting the leukocyte immune system's role in IBD pathogenesis.
- Findings offer novel research avenues for clinical prevention and treatment strategies targeting IBD.
More Related Videos
08:37Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
05:28Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
Published on: May 2, 2022
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...