Fructosamine and HbA1c: A Correlational Study in a Southeast Asian Population

Area of Science:

• Endocrinology
• Clinical Chemistry

Background:

• Glycated haemoglobin (HbA1c) is a key marker for diabetes management.
• Fructosamine's correlation with HbA1c is established in Caucasian populations.

Purpose of the Study:

• To investigate the correlation between fructosamine and HbA1c in Southeast Asians.
• To determine if fructosamine can reliably estimate HbA1c in this demographic.

Main Methods:

• 193 participants from Singapore were recruited based on HbA1c levels.
• Blood samples were analyzed for fructosamine, HbA1c, albumin, hemoglobin, TSH, and creatinine.
• Pearson's correlation coefficient and simple linear regression were employed.

Main Results:

• A significant linear correlation was observed between fructosamine and HbA1c (R² = 0.756, p<0.01).
• Natural logarithmic transformation of fructosamine enhanced the correlation (R² = 0.792, p<0.01).

Conclusions:

• Fructosamine demonstrates a reliable correlation with HbA1c in Southeast Asians.
• Fructosamine can be utilized for effective glycaemic control monitoring in this population.