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[Antiarrhythmic agents in tinnitus treatment]
Laryngologie, Rhinologie, Otologie
|March 1, 1985
Summary
Intravenous lidocaine effectively suppressed tinnitus in over half of patients with sensorineural hearing loss. This treatment also showed measurable electrophysiological changes, suggesting a potential therapeutic mechanism for tinnitus management.
Area of Science:
- Otolaryngology
- Neuroscience
- Pharmacology
Background:
- Tinnitus treatment is challenging due to the lack of objective diagnostic parameters.
- Rational tinnitus treatment requires objective assessment criteria.
- Sensorineural hearing loss often presents with a well-defined tinnitus symptom.
Purpose of the Study:
- To evaluate the efficacy of intravenous lidocaine in managing tinnitus patients.
- To assess the impact of lidocaine on subjective tinnitus perception.
- To investigate electrophysiological changes associated with lidocaine treatment for tinnitus.
Main Methods:
- A randomized, blind-controlled, cross-over trial was conducted.
- 20 patients with sensorineural hearing loss and tinnitus received intravenous lidocaine or saline.
- Brainstem Evoked Response Audiometry (BERA) was used to monitor electrophysiological changes.
Main Results:
- 13 out of 20 patients reported over 50% tinnitus suppression with lidocaine.
- No significant tinnitus suppression was observed with saline treatment.
- Lidocaine administration resulted in reversible lengthening of central conduction time in BERA, without hearing impairment.
Conclusions:
- Intravenous lidocaine demonstrates significant potential for tinnitus suppression in patients with sensorineural hearing loss.
- Lidocaine's therapeutic effect on tinnitus may be linked to electrophysiological alterations.
- Further research into the mechanisms of lidocaine action in tinnitus is warranted.