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Increased interleukin II production during kidney allograft rejection
Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
|January 1, 1985
Summary
Kidney transplant recipients show low Interleukin II (IL-2) production by peripheral blood leucocytes (PBL) with well-functioning grafts. Acute rejection episodes correlate with a significant rise in IL-2 levels, suggesting its role in graft rejection.
Area of Science:
- Immunology
- Transplantation Science
- Cellular Biology
Background:
- Interleukin II (IL-2) is a key cytokine in immune responses.
- Monitoring immune cell function is crucial in kidney transplant recipients.
Purpose of the Study:
- To investigate the lectin-induced production of IL-2 by peripheral blood leucocytes (PBL) in kidney graft recipients.
- To correlate IL-2 production levels with graft function and rejection episodes.
Main Methods:
- Peripheral blood leucocytes (PBL) were isolated from kidney transplant recipients and healthy individuals.
- Lectin-induced IL-2 production was measured in vitro.
- IL-2 levels were compared between pre-graft, post-graft (well-functioning), and during acute rejection phases.
Main Results:
- Pre-graft IL-2 production in haemodialysed patients was comparable to healthy individuals.
- Recipients with well-functioning grafts exhibited significantly lower IL-2 production one year post-transplant (p < 0.001).
- IL-2 production tended to restore years after grafting and significantly increased at the onset of acute rejection.
Conclusions:
- Reduced IL-2 production is characteristic of well-functioning kidney grafts.
- Elevated IL-2 production may indicate or contribute to acute kidney transplant rejection.
- IL-2 monitoring could offer insights into graft status and rejection risk.