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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

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Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: Jun 23, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

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Nevi and Melanoma.

Yifan Zhang1, Stephen M Ostrowski1, David E Fisher1

  • 1Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA; Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.

Hematology/Oncology Clinics of North America
|June 16, 2024
PubMed
Summary
This summary is machine-generated.

Cutaneous melanoma, a dangerous skin cancer, often arises from benign nevi. Despite shared mutations, distinguishing benign nevi from malignant melanoma clinically remains difficult.

Keywords:
Atypical nevusDysplastic nevusMelanomaNevusSenescence

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The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
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Area of Science:

  • Dermatology
  • Oncology
  • Molecular Biology

Background:

  • Cutaneous melanoma is an aggressive skin cancer originating from melanocytes, leading to significant morbidity and mortality.
  • Melanomas frequently develop from precursor lesions known as nevi, which are benign melanocyte proliferations.
  • Both benign nevi and malignant melanoma share identical oncogenic driver mutations.

Purpose of the Study:

  • To investigate the relationship between benign nevi and cutaneous melanoma.
  • To understand the molecular pathways involved in nevus formation and melanoma transformation.
  • To address the diagnostic challenges in differentiating benign nevi from malignant melanoma.

Main Methods:

  • Review of existing literature on nevus formation and melanoma development.
  • Analysis of molecular data linking mutations in nevi and melanoma.
  • Clinical case studies and diagnostic criteria evaluation.

Main Results:

  • Identical oncogenic mutations are present in both benign nevi and cutaneous melanoma.
  • Nevi represent a significant precursor lesion for melanoma development.
  • Clinical differentiation between benign nevi and early melanoma is challenging.

Conclusions:

  • Understanding the molecular basis of nevus-melanoma transition is crucial.
  • Improved diagnostic tools are needed to accurately distinguish benign nevi from malignant melanoma.
  • Further research into nevus biology may reveal new therapeutic targets for melanoma.