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Updated: Jun 23, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
[THE MUSCULAR COMPONENT OF FIBROMYALGIA PATHOPHYSIOLOGY]
Daniel Yechiali1, Liel Katbi1, Gilad Halpert1
1Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, The Arrow Program, Sheba Medical Center, Israel; Sackler Faculty of Medicine, Tel-Aviv University Tel-Aviv, Israel Arrow Program for Medical Research Education Sheba Medical Center, Tel Hashomer, Israel.
Introduction:
Fibromyalgia syndrome (FMS) is a chronic pain syndrome, prevalent in women more than men. The main symptoms are widespread musculoskeletal pain, fatigue, and weakness. To date, the pathophysiological mechanisms are unclear, and there are several pathogenic theories elucidating this condition. In this review, we summarized articles published in the past few years, regarding the effect of musculoskeletal dysfunction on FMS. We focused on the musculoskeletal system and central nervous system (CNS) disarrays.
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