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Updated: Jun 23, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts
Elisa Mazza1,2, Ersilia Troiano2,3, Yvelise Ferro4
1Department of Clinical and Experimental Medicine, University Magna Græcia, 88100 Catanzaro, Italy.
Diet impacts hormonal balance and metabolic health, especially in obesity. Personalized nutrition, considering gender, is key for better health outcomes.
Area of Science:
- Endocrinology
- Nutritional Science
- Metabolic Health
Background:
- Obesity is linked to endocrine disruptions and metabolic dysfunction.
- Hormonal balance is critical for overall health and is influenced by diet.
- Gender-specific factors play a role in metabolic health and disease susceptibility.
Purpose of the Study:
- To review the impact of various dietary patterns on hormonal regulation in men and women.
- To analyze how different diets affect hormonal balance and metabolic health in obesity.
- To identify future research directions for personalized, gender-sensitive dietary interventions.
Main Methods:
- Narrative review of existing literature.
- Analysis of dietary patterns including calorie restriction, Western, high-fat, low-carbohydrate, plant-based, and Mediterranean diets.
- Focus on hormonal regulation, endocrine disruptions, and metabolic health in the context of obesity.
Main Results:
- Dietary patterns significantly influence hormonal regulation and metabolic health.
- Obesity exacerbates diet-related endocrine disruptions.
- Gender differences in metabolic response to diet warrant further investigation.
Conclusions:
- Personalized dietary interventions tailored to individual metabolic and hormonal profiles are essential.
- Integrating gender-specific considerations into dietary recommendations can optimize health outcomes.
- Further research is needed to elucidate specific mechanisms and gender-based differences.
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