Aqueous-Aqueous Triboelectric Nanogenerators Empowered Multifunctional Wound Healing System with Intensified Current...

Area of Science:

• Biomedical Engineering
• Materials Science
• Regenerative Medicine

Background:

• Triboelectric nanogenerators (TENGs) offer self-powered electrical stimulation for wound healing.
• Conventional TENGs face limitations in achieving full contact, hindering current output and healing efficacy.
• Infected wounds require advanced therapeutic strategies for effective management.

Purpose of the Study:

• To develop a novel multifunctional wound healing system integrating aqueous-aqueous TENGs (A-A TENGs) with a conductive hydrogel.
• To enhance therapeutic electrical stimulation for infected wound treatment.
• To investigate the system's efficacy in promoting various aspects of wound healing.

Main Methods:

• Integration of A-A TENGs, based on 100% contact interface and efficient separation in aqueous two-phase systems (ATPS), with a functionalized conductive hydrogel.
• In vitro and in vivo testing on infected wounds.
• Evaluation of fibroblast migration, proliferation, angiogenesis, collagen deposition, bacterial eradication, and inflammatory cell reduction.

Main Results:

• The A-A TENGs achieved enhanced charge transfer and increased current performance due to their unique interface principle.
• The integrated system demonstrated significant therapeutic effects on infected wounds, promoting accelerated healing.
• Synergistic effects from the conductive hydrogel ensured uniform electric field distribution and added therapeutic benefits.

Conclusions:

• The developed A-A TENGs empowered multifunctional wound healing system shows excellent potential for clinical application in infected wound therapy.
• The system effectively enhances electrical stimulation for improved wound healing outcomes.
• This innovation represents a significant advancement in self-powered therapeutic devices for regenerative medicine.